Micardis/Micardis Plus Overdosage

Symptoms: Limited information is available with regard to overdose in humans.
The most prominent manifestations of telmisartan overdose were hypotension and tachycardia; bradycardia also occured. If symptomatic hypotension should occur, supportive treatment should be instituted. Telmisartan is not removed by hemodialysis.
Overdose with hydrochlorothiazide is associated with electrolyte depletion (hypokalaemia, hypochloraemia) and dehydration resulting from excessive diuresis. The most common signs and symptoms of overdose are nausea and somnolence. Hypokalaemia may result in muscle spasm and/or accentuate cardiac arrhythmias associated with the concomitant use of digitalis glycosides or certain antiarrhythmic drugs.
Treatment: No specific information is available on the treatment of overdose with Micardis Plus. The patient should be closely monitored and the treatment should be symptomatic and supportive depending on the time since ingestion and the severity of symptoms. Serum electrolytes and creatinine should be monitored frequently. If hypotension occurs, the patients should be placed in a supine position, with salt and volume replacement given quickly. Telmisartan is not removed by hemodialysis. The degree to which hydrochlorothiazide is removed by hemodialysis has not been established.